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SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts
During DNA synthesis, DNA replication and transcription machinery can collide, and the replication fork may temporarily dislodge RNA polymerase II (RNAPII) to resolve the transcription-replication conflict (TRC), a major source of endogenous DNA double-strand breaks (DSBs) and common fragile site (C...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045570/ https://www.ncbi.nlm.nih.gov/pubmed/30006506 http://dx.doi.org/10.1038/s41467-018-05236-y |