Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations

Anaplastic lymphoma kinase (ALK) is considered as a validated molecular target in multiple malignancies, such as non-small cell lung cancer (NSCLC). However, the effectiveness of molecularly targeted therapies using ALK inhibitors is almost universally limited by drug resistance. Drug resistance to...

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Detalles Bibliográficos
Autores principales: Li, Jianzong, Huang, Yue, Wu, Miaomiao, Wu, Chuanfang, Li, Xin, Bao, Jinku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045602/
https://www.ncbi.nlm.nih.gov/pubmed/30006516
http://dx.doi.org/10.1038/s41598-018-28752-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045602/
https://www.ncbi.nlm.nih.gov/pubmed/30006516
http://dx.doi.org/10.1038/s41598-018-28752-9

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