Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A(2) and mediates its toxic activity

Phospholipases A(2) are a major component of snake venoms. Some of them cause severe muscle necrosis through an unknown mechanism. Phospholipid hydrolysis is a possible explanation of their toxic action, but catalytic and toxic properties of PLA(2)s are not directly connected. In addition, viperid v...

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Detalles Bibliográficos
Autores principales: Massimino, Maria Lina, Simonato, Morena, Spolaore, Barbara, Franchin, Cinzia, Arrigoni, Giorgio, Marin, Oriano, Monturiol-Gross, Laura, Fernández, Julián, Lomonte, Bruno, Tonello, Fiorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045611/
https://www.ncbi.nlm.nih.gov/pubmed/30006575
http://dx.doi.org/10.1038/s41598-018-28846-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045611/
https://www.ncbi.nlm.nih.gov/pubmed/30006575
http://dx.doi.org/10.1038/s41598-018-28846-4

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