VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation

VHL inactivation is a key oncogenic event for renal carcinomas. In normoxia, VHL suppresses HIF1a-mediated transcriptional response, which is characteristic to hypoxia. It has previously been shown that hypoxic conditions inhibit TET-dependent hydroxymethylation of cytosines and cause DNA hypermethy...

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Detalles Bibliográficos
Autores principales: Artemov, Artem V., Zhigalova, Nadezhda, Zhenilo, Svetlana, Mazur, Alexander M., Prokhortchouk, Egor B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045645/
https://www.ncbi.nlm.nih.gov/pubmed/30006568
http://dx.doi.org/10.1038/s41598-018-28795-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045645/
https://www.ncbi.nlm.nih.gov/pubmed/30006568
http://dx.doi.org/10.1038/s41598-018-28795-y

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