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Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases

Brain metastases are devastating complications of cancer. The blood–brain barrier (BBB), which protects the normal brain, morphs into an inadequately characterized blood–tumor barrier (BTB) when brain metastases form, and is surrounded by a neuroinflammatory response. These structures contribute to...

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Detalles Bibliográficos
Autores principales: Gril, Brunilde, Paranjape, Anurag N., Woditschka, Stephan, Hua, Emily, Dolan, Emma L., Hanson, Jeffrey, Wu, Xiaolin, Kloc, Wojciech, Izycka-Swieszewska, Ewa, Duchnowska, Renata, Pęksa, Rafał, Biernat, Wojciech, Jassem, Jacek, Nayyar, Naema, Brastianos, Priscilla K., Hall, O. Morgan, Peer, Cody J., Figg, William D., Pauly, Gary T., Robinson, Christina, Difilippantonio, Simone, Bialecki, Emilie, Metellus, Philippe, Schneider, Joel P., Steeg, Patricia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045677/
https://www.ncbi.nlm.nih.gov/pubmed/30006619
http://dx.doi.org/10.1038/s41467-018-05030-w