CART cells are prone to Fas- and DR5-mediated cell death

Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that CART cells progressively upregulate Fas, FasL...

Descripción completa

Detalles Bibliográficos
Autores principales: Tschumi, Benjamin O., Dumauthioz, Nina, Marti, Bastien, Zhang, Lianjun, Schneider, Pascal, Mach, Jean-Pierre, Romero, Pedro, Donda, Alena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045821/
https://www.ncbi.nlm.nih.gov/pubmed/30005714
http://dx.doi.org/10.1186/s40425-018-0385-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045821/
https://www.ncbi.nlm.nih.gov/pubmed/30005714
http://dx.doi.org/10.1186/s40425-018-0385-z

Ejemplares similares