Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest

Temozolomide (TMZ) is the first-line chemotherapeutic agent in the treatment of glioblastoma multiforme (GBM). Despite its cytotoxic effect, TMZ also induces cell cycle arrest that may lead to the development of chemoresistance and eventual tumor recurrence. Caffeine, a widely consumed neurostimulan...

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Detalles Bibliográficos
Autores principales: Li, Ning, Zhang, Pingde, Kiang, Karrie Mei Yee, Cheng, Yin Stephen, Leung, Gilberto Ka Kit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046144/
https://www.ncbi.nlm.nih.gov/pubmed/30050935
http://dx.doi.org/10.1155/2018/5364973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046144/
https://www.ncbi.nlm.nih.gov/pubmed/30050935
http://dx.doi.org/10.1155/2018/5364973

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