Cone Phosphodiesterase-6γ’ Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits

Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ subunits, while cone PDE6 is composed of two identical PDE6α’ catalytic subunits and two identi...

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Detalles Bibliográficos
Autores principales: Deng, Wen-Tao, Kolandaivelu, Saravanan, Dinculescu, Astra, Li, Jie, Zhu, Ping, Chiodo, Vince A., Ramamurthy, Visvanathan, Hauswirth, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046437/
https://www.ncbi.nlm.nih.gov/pubmed/30038560
http://dx.doi.org/10.3389/fnmol.2018.00233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046437/
https://www.ncbi.nlm.nih.gov/pubmed/30038560
http://dx.doi.org/10.3389/fnmol.2018.00233

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