MiR‐21 role in aspirin‐dependent PPARα and multidrug resistance protein 4 upregulation

BACKGROUND: A mechanism involved in high on‐aspirin treatment residual platelet reactivity is platelet multidrug resistance protein 4 (MRP4) overexpression. Aspirin enhances platelet MRP4 expression with a PPARα‐dependent mechanism and reduces miR‐21 expression that, in turn, downregulates PPARα exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Massimi, Isabella, Alemanno, Laura, Guarino, Maria L., Guerriero, Raffaella, Frati, Luigi, Biasucci, Luigi, Pulcinelli, Fabio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Online‐only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046603/
https://www.ncbi.nlm.nih.gov/pubmed/30046765
http://dx.doi.org/10.1002/rth2.12104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046603/
https://www.ncbi.nlm.nih.gov/pubmed/30046765
http://dx.doi.org/10.1002/rth2.12104

Ejemplares similares