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MiR‐21 role in aspirin‐dependent PPARα and multidrug resistance protein 4 upregulation
BACKGROUND: A mechanism involved in high on‐aspirin treatment residual platelet reactivity is platelet multidrug resistance protein 4 (MRP4) overexpression. Aspirin enhances platelet MRP4 expression with a PPARα‐dependent mechanism and reduces miR‐21 expression that, in turn, downregulates PPARα exp...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046603/ https://www.ncbi.nlm.nih.gov/pubmed/30046765 http://dx.doi.org/10.1002/rth2.12104 |