Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer

BACKGROUND: Somatic mutations in the ERBB genes (epidermal growth factor receptor: EGFR, ERBB2, ERBB3, ERBB4) promote oncogenesis and lapatinib resistance in metastatic HER2+ (human epidermal growth factor-like receptor 2) breast cancer in vitro. Our study aimed to determine the frequency of mutatio...

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Detalles Bibliográficos
Autores principales: Elster, Naomi, Toomey, Sinead, Fan, Yue, Cremona, Mattia, Morgan, Clare, Weiner Gorzel, Karolina, Bhreathnach, Una, Milewska, Malgorzata, Murphy, Madeline, Madden, Stephen, Naidoo, Jarushka, Fay, Joanna, Kay, Elaine, Carr, Aoife, Kennedy, Sean, Furney, Simon, Mezynski, Janusz, Breathhnach, Oscar, Morris, Patrick, Grogan, Liam, Hill, Arnold, Kennedy, Susan, Crown, John, Gallagher, William, Hennessy, Bryan, Eustace, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047239/
https://www.ncbi.nlm.nih.gov/pubmed/30023006
http://dx.doi.org/10.1177/1758835918778297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047239/
https://www.ncbi.nlm.nih.gov/pubmed/30023006
http://dx.doi.org/10.1177/1758835918778297

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