Strategic and Statistical Considerations on the QT Assessment of Volasertib

Volasertib is a selective cell cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kinase (Plk). A potential for prolonged QT intervals was indicated with volasertib in preclinical studies and preliminary clinical data. As a result, electrocardiograms (ECGs) have...

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Detalles Bibliográficos
Autores principales: Wallenstein, Gudrun, Walter, Beate, Fritsch, Holger, Taube, Tillmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Biostatistics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047300/
https://www.ncbi.nlm.nih.gov/pubmed/29714574
http://dx.doi.org/10.1177/2168479017739826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047300/
https://www.ncbi.nlm.nih.gov/pubmed/29714574
http://dx.doi.org/10.1177/2168479017739826

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