Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs

The potent transcription inhibitor Actinomycin D is used with several cancers. Here, we report the discovery that this naturally occurring antibiotic inhibits two human neutral aminopeptidases, the cell-surface alanine aminopeptidase and intracellular methionine aminopeptidase type 2. These metallo-...

Descripción completa

Detalles Bibliográficos
Autores principales: Węglarz-Tomczak, Ewelina, Talma, Michał, Giurg, Mirosław, Westerhoff, Hans V., Janowski, Robert, Mucha, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047675/
https://www.ncbi.nlm.nih.gov/pubmed/30034623
http://dx.doi.org/10.18632/oncotarget.25532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047675/
https://www.ncbi.nlm.nih.gov/pubmed/30034623
http://dx.doi.org/10.18632/oncotarget.25532

Ejemplares similares