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Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs

The potent transcription inhibitor Actinomycin D is used with several cancers. Here, we report the discovery that this naturally occurring antibiotic inhibits two human neutral aminopeptidases, the cell-surface alanine aminopeptidase and intracellular methionine aminopeptidase type 2. These metallo-...

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Detalles Bibliográficos
Autores principales:	Węglarz-Tomczak, Ewelina, Talma, Michał, Giurg, Mirosław, Westerhoff, Hans V., Janowski, Robert, Mucha, Artur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047675/ https://www.ncbi.nlm.nih.gov/pubmed/30034623 http://dx.doi.org/10.18632/oncotarget.25532

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