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Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells

Long noncoding RNAs (lncRNAs) are emerging as key players in multiple cellular pathways1, but their modes of action, and how those are dictated by sequence remain elusive. lncRNAs tend to be enriched in the nuclear fraction, whereas most mRNAs are overtly cytoplasmic2, although several studies have...

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Detalles Bibliográficos
Autores principales: Lubelsky, Yoav, Ulitsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047738/
https://www.ncbi.nlm.nih.gov/pubmed/29466324
http://dx.doi.org/10.1038/nature25757