Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory formation by synaptic remodeling. Substrate profiles of recombinant KLK8 were analyzed with positional scanning using fluorogenic tetrapeptides...

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Detalles Bibliográficos
Autores principales: Debela, Mekdes, Magdolen, Viktor, Skala, Wolfgang, Elsässer, Brigitta, Schneider, Eric L., Craik, Charles S., Biniossek, Martin L., Schilling, Oliver, Bode, Wolfram, Brandstetter, Hans, Goettig, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048020/
https://www.ncbi.nlm.nih.gov/pubmed/30013126
http://dx.doi.org/10.1038/s41598-018-29058-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048020/
https://www.ncbi.nlm.nih.gov/pubmed/30013126
http://dx.doi.org/10.1038/s41598-018-29058-6

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