A CpG-adjuvanted intranasal enterovirus 71 vaccine elicits mucosal and systemic immune responses and protects human SCARB2-transgenic mice against lethal challenge

Enterovirus 71 (EV71) is an aetiological agent responsible for seasonal epidemics of hand-foot-and-mouth disease, which causes considerable mortality among young children. Mucosal vaccines can efficiently induce secretory IgA at mucosal surfaces and thereby prevent or limit infection at the site of...

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Detalles Bibliográficos
Autores principales: Lin, Yu-Li, Chow, Yen-Hung, Huang, Li-Min, Hsieh, Szu-Min, Cheng, Pei-Yun, Hu, Kai-Chieh, Chiang, Bor-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048030/
https://www.ncbi.nlm.nih.gov/pubmed/30013088
http://dx.doi.org/10.1038/s41598-018-28281-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048030/
https://www.ncbi.nlm.nih.gov/pubmed/30013088
http://dx.doi.org/10.1038/s41598-018-28281-5

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