ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Cells respond to cytotoxic DNA double-strand breaks by recruiting repair proteins to the damaged site. Phosphorylation of the histone variant H2AX at S139 and Y142 modulate its interaction with downstream DNA repair proteins and their recruitment to DNA lesions. Here we report ATM-dependent ZNF506 l...

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Detalles Bibliográficos
Autores principales: Nowsheen, Somaira, Aziz, Khaled, Luo, Kuntian, Deng, Min, Qin, Bo, Yuan, Jian, Jeganathan, Karthik B., Yu, Jia, Zhang, Henan, Ding, Wei, van Deursen, Jan M., Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048040/
https://www.ncbi.nlm.nih.gov/pubmed/30013081
http://dx.doi.org/10.1038/s41467-018-05161-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048040/
https://www.ncbi.nlm.nih.gov/pubmed/30013081
http://dx.doi.org/10.1038/s41467-018-05161-0

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