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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
Cells respond to cytotoxic DNA double-strand breaks by recruiting repair proteins to the damaged site. Phosphorylation of the histone variant H2AX at S139 and Y142 modulate its interaction with downstream DNA repair proteins and their recruitment to DNA lesions. Here we report ATM-dependent ZNF506 l...
Autores principales: | Nowsheen, Somaira, Aziz, Khaled, Luo, Kuntian, Deng, Min, Qin, Bo, Yuan, Jian, Jeganathan, Karthik B., Yu, Jia, Zhang, Henan, Ding, Wei, van Deursen, Jan M., Lou, Zhenkun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048040/ https://www.ncbi.nlm.nih.gov/pubmed/30013081 http://dx.doi.org/10.1038/s41467-018-05161-0 |
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