A V-to-F substitution in SK2 channels causes Ca(2+) hypersensitivity and improves locomotion in a C. elegans ALS model

Small-conductance Ca(2+)-activated K(+) (SK) channels mediate medium afterhyperpolarization in the neurons and play a key role in the regulation of neuronal excitability. SK channels are potential drug targets for ataxia and Amyotrophic Lateral Sclerosis (ALS). SK channels are activated exclusively...

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Detalles Bibliográficos
Autores principales: Nam, Young-Woo, Baskoylu, Saba N., Gazgalis, Dimitris, Orfali, Razan, Cui, Meng, Hart, Anne C., Zhang, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048120/
https://www.ncbi.nlm.nih.gov/pubmed/30013223
http://dx.doi.org/10.1038/s41598-018-28783-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048120/
https://www.ncbi.nlm.nih.gov/pubmed/30013223
http://dx.doi.org/10.1038/s41598-018-28783-2

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