A V-to-F substitution in SK2 channels causes Ca(2+) hypersensitivity and improves locomotion in a C. elegans ALS model

Small-conductance Ca(2+)-activated K(+) (SK) channels mediate medium afterhyperpolarization in the neurons and play a key role in the regulation of neuronal excitability. SK channels are potential drug targets for ataxia and Amyotrophic Lateral Sclerosis (ALS). SK channels are activated exclusively...

Descripción completa

Detalles Bibliográficos
Autores principales: Nam, Young-Woo, Baskoylu, Saba N., Gazgalis, Dimitris, Orfali, Razan, Cui, Meng, Hart, Anne C., Zhang, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048120/
https://www.ncbi.nlm.nih.gov/pubmed/30013223
http://dx.doi.org/10.1038/s41598-018-28783-2

Ejemplares similares

Ejemplares similares