Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis

Insulin stimulates lipogenesis but insulin resistance is also associated with increased hepatic lipogenesis in obesity. However, the underlying mechanism remains poorly characterized. Here, we show a noncanonical insulin-Snail1 pathway that suppresses lipogenesis. Insulin robustly upregulates zinc-f...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Jiang, Lin, Sun, Chengxin, Ireland, Nicole, Shah, Yatrik M., Liu, Yong, Rui, Liangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048127/
https://www.ncbi.nlm.nih.gov/pubmed/30013137
http://dx.doi.org/10.1038/s41467-018-05309-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048127/
https://www.ncbi.nlm.nih.gov/pubmed/30013137
http://dx.doi.org/10.1038/s41467-018-05309-y

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