Cargando…

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

Genetic aberrations driving pro-oncogenic and pro-metastatic activity remain an elusive target in the quest of precision oncology. To identify such drivers, we use an animal model of KRAS-mutant lung adenocarcinoma to perform an in vivo functional screen of 217 genetic aberrations selected from lung...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grzeskowiak, Caitlin L., Kundu, Samrat T., Mo, Xiulei, Ivanov, Andrei A., Zagorodna, Oksana, Lu, Hengyu, Chapple, Richard H., Tsang, Yiu Huen, Moreno, Daniela, Mosqueda, Maribel, Eterovic, Karina, Fradette, Jared J., Ahmad, Sumreen, Chen, Fengju, Chong, Zechen, Chen, Ken, Creighton, Chad J., Fu, Haian, Mills, Gordon B., Gibbons, Don L., Scott, Kenneth L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048166/ https://www.ncbi.nlm.nih.gov/pubmed/30013058 http://dx.doi.org/10.1038/s41467-018-04572-3

Ejemplares similares

IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion.
por: Bajaj, Rakhee, et al.
Publicado: (2020)

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
por: Kundu, Samrat T., et al.
Publicado: (2018)

De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder
por: Werren, Elizabeth A., et al.
Publicado: (2023)

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression
por: Tsang, Yiu Huen, et al.
Publicado: (2020)

Modeling GATAD1-Associated Dilated Cardiomyopathy in Adult Zebrafish
por: Yang, Jingchun, et al.
Publicado: (2016)

Functional annotation of rare gene aberration drivers of pancreatic cancer
por: Tsang, Yiu Huen, et al.
Publicado: (2016)

MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs
por: Ochieng, Joshua Kapere, et al.
Publicado: (2020)

GATAD1 gene amplification promotes glioma malignancy by directly regulating CCND1 transcription
por: Zhang, Shanshan, et al.
Publicado: (2019)

Effect of GATAD1 regulating the SRRM2 gene on recurrence of thyroid tumor and its molecular mechanism
por: Wang, Xingquan, et al.
Publicado: (2022)

ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis
por: Perez-Oquendo, Mabel, et al.
Publicado: (2023)

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
por: Manshouri, Roxsan, et al.
Publicado: (2019)

Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis
por: Yao, Yao, et al.
Publicado: (2019)

MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression
por: Guo, Le, et al.
Publicado: (2022)

The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8(+) cytotoxic T-cell response
por: Kundu, Samrat T., et al.
Publicado: (2022)

Correction to: Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis
por: Yao, Yao, et al.
Publicado: (2020)

The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers
por: Kundu, Samrat T., et al.
Publicado: (2015)

lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR-3180 and regulating GATAD2A expression
por: Zhang, Mi, et al.
Publicado: (2022)

Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer
por: Konen, Jessica M., et al.
Publicado: (2019)

A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators
por: Tang, Cong, et al.
Publicado: (2021)

Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer
por: Padhye, Aparna, et al.
Publicado: (2021)

The Good, the Bad and the Unknown of CD38 in the Metabolic Microenvironment and Immune Cell Functionality of Solid Tumors
por: Konen, Jessica M., et al.
Publicado: (2019)

2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines
por: Zagorodna, Oksana, et al.
Publicado: (2011)

SVExpress: identifying gene features altered recurrently in expression with nearby structural variant breakpoints
por: Zhang, Yiqun, et al.
Publicado: (2021)

Systematic identification of non-coding somatic single nucleotide variants associated with altered transcription and DNA methylation in adult and pediatric cancers
por: Chen, Fengju, et al.
Publicado: (2021)

Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs
por: Zhang, Yiqun, et al.
Publicado: (2023)

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers
por: Peng, David H., et al.
Publicado: (2021)

Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas
por: Reyes-Castro, Raisa A., et al.
Publicado: (2023)

Impad1 and Syt11 work in an epistatic pathway that regulates EMT-mediated vesicular trafficking to drive lung cancer invasion and metastasis
por: Bajaj, Rakhee, et al.
Publicado: (2022)

Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period
por: Beddok, Arnaud, et al.
Publicado: (2021)

Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies
por: Rathmell, Kimryn W., et al.
Publicado: (2015)

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening
por: Du, Yuhong, et al.
Publicado: (2020)

ClinSeK: a targeted variant characterization framework for clinical sequencing
por: Zhou, Wanding, et al.
Publicado: (2015)

Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
por: Bajaj, Rakhee, et al.
Publicado: (2022)

PMON184 Ligand-dependent interaction between phosphatidylcholine transfer protein and PPARδ: therapeutic implications for metabolic syndrome
por: Druzak, Samuel, et al.
Publicado: (2022)

Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers
por: Chen, Fengju, et al.
Publicado: (2019)

Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2019)

Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2020)

Pan-urologic cancer genomic subtypes that transcend tissue of origin
por: Chen, Fengju, et al.
Publicado: (2017)

Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers
por: Adachi, Yuta, et al.
Publicado: (2021)

Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
por: Zhang, Yiqun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sfn39k5gojq8htv544n69td604