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Differential In Vitro Cultivation of Francisella tularensis Influences Live Vaccine Protective Efficacy by Altering the Immune Response

Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and improved tools to assess these vaccines. Ft expresses distinct sets of antigens (Ags) in vivo as compared to those express...

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Detalles Bibliográficos
Autores principales: Sunagar, Raju, Kumar, Sudeep, Rosa, Sarah J., Hazlett, Karsten R. O., Gosselin, Edmund J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048226/
https://www.ncbi.nlm.nih.gov/pubmed/30042767
http://dx.doi.org/10.3389/fimmu.2018.01594