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Acidosis and Phosphate Directly Reduce Myosin’s Force-Generating Capacity Through Distinct Molecular Mechanisms

Elevated levels of the metabolic by-products, including acidosis (i.e., high [H(+)]) and phosphate (P(i)) are putative agents of muscle fatigue; however, the mechanism through which they affect myosin’s function remain unclear. To elucidate these mechanisms, we directly examined the effect of acidos...

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Detalles Bibliográficos
Autores principales: Woodward, Mike, Debold, Edward P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048269/
https://www.ncbi.nlm.nih.gov/pubmed/30042692
http://dx.doi.org/10.3389/fphys.2018.00862