Cargando…

Elucidating T Cell Activation-Dependent Mechanisms for Bifurcation of Regulatory and Effector T Cell Differentiation by Multidimensional and Single-Cell Analysis

In T cells, T cell receptor (TCR) signaling initiates downstream transcriptional mechanisms for T cell activation and differentiation. Foxp3-expressing regulatory T cells (Treg) require TCR signals for their suppressive function and maintenance in the periphery. It is, however, unclear how TCR signa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bradley, Alla, Hashimoto, Tetsuo, Ono, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048294/ https://www.ncbi.nlm.nih.gov/pubmed/30061879 http://dx.doi.org/10.3389/fimmu.2018.01444

Ejemplares similares

Differential Sensitivity of Regulatory and Effector T Cells to Cell Death: A Prerequisite for Transplant Tolerance
por: You, Sylvaine
Publicado: (2015)

PKC-Theta in Regulatory and Effector T-cell Functions
por: Brezar, Vedran, et al.
Publicado: (2015)

Lineage Reprogramming of Effector Regulatory T Cells in Cancer
por: Dixon, Michael L., et al.
Publicado: (2021)

Chloroquine Suppresses Effector B-Cell Functions and Has Differential Impact on Regulatory B-Cell Subsets
por: Ma, Xin, et al.
Publicado: (2022)

The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level
por: Buchholz, Veit R., et al.
Publicado: (2013)

Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny
por: Dowling, Mark R., et al.
Publicado: (2018)

JunB Controls Intestinal Effector Programs in Regulatory T Cells
por: Wheaton, Joshua D., et al.
Publicado: (2020)

Responses of regulatory and effector T-cells to low-dose interleukin-2 differ depending on the immune environment after allogeneic stem cell transplantation
por: Meguri, Yusuke, et al.
Publicado: (2022)

Epigenetic regulation of NK cell differentiation and effector functions
por: Cichocki, Frank, et al.
Publicado: (2013)

Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naïve Mice
por: Zhu, Kun, et al.
Publicado: (2020)

Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting
por: Andriamanantena, Zo, et al.
Publicado: (2022)

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses
por: Höfer, Thomas, et al.
Publicado: (2012)

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation
por: Verstegen, Niels J. M., et al.
Publicado: (2021)

CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner
por: Campos-Mora, Mauricio, et al.
Publicado: (2019)

Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage
por: Geng, Shuang, et al.
Publicado: (2017)

Phenotypic and Functional Changes of Peripheral Ly6C(+) T Regulatory Cells Driven by Conventional Effector T Cells
por: Lee, Jun Young, et al.
Publicado: (2018)

Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression
por: Harpaz, Idan, et al.
Publicado: (2017)

PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis
por: Pereira, Joseph A., et al.
Publicado: (2023)

Harnessing the Heterogeneity of T Cell Differentiation Fate to Fine-Tune Generation of Effector and Memory T Cells
por: Gong, Chang, et al.
Publicado: (2014)

Single-Cell Analysis Revealed the Role of CD8(+) Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure
por: Komai, Kyoko, et al.
Publicado: (2021)

Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha
por: Sailliet, Nicolas, et al.
Publicado: (2023)

Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
por: Chen, Yao, et al.
Publicado: (2018)

Metabolic alterations impair differentiation and effector functions of CD8+ T cells
por: Bensussen, Antonio, et al.
Publicado: (2022)

PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection
por: Tinoco, Roberto, et al.
Publicado: (2021)

The Significance of Tumor Necrosis Factor Receptor Type II in CD8(+) Regulatory T Cells and CD8(+) Effector T Cells
por: Ye, Lin-Lin, et al.
Publicado: (2018)

Notch controls effector CD8(+) T cell differentiation
por: Duval, Frédéric, et al.
Publicado: (2015)

Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity
por: Haug, Tabea, et al.
Publicado: (2019)

Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4(+) T Effector and Regulatory T Cells in Cutaneous Leishmaniasis
por: de Freitas e Silva, Rafael, et al.
Publicado: (2020)

Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development
por: Kurtulus, Sema, et al.
Publicado: (2013)

How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets
por: Wang, Haiguang, et al.
Publicado: (2018)

Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions
por: Alvarez, Fernando, et al.
Publicado: (2019)

Active Tuberculosis Is Characterized by Highly Differentiated Effector Memory Th1 Cells
por: Arrigucci, Riccardo, et al.
Publicado: (2018)

ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells
por: Cheng, Zhong-Yan, et al.
Publicado: (2021)

Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans
por: Tsuda, Sayaka, et al.
Publicado: (2018)

p53 Activation Effect in the Balance of T Regulatory and Effector Cell Subsets in Patients With Thyroid Cancer and Autoimmunity
por: Arena, Andrea, et al.
Publicado: (2021)

Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
por: Zaongo, Silvere D., et al.
Publicado: (2022)

Transcriptional Regulation of Differentiation and Functions of Effector T Regulatory Cells
por: Koizumi, Shin-ichi, et al.
Publicado: (2019)

Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma
por: Lee, Lydia, et al.
Publicado: (2021)

Effector Memory T Cells and CD45RO+ Regulatory T Cells in Metastatic vs. Non-Metastatic Lymph Nodes in Lung Cancer Patients
por: Kwiecień, Iwona, et al.
Publicado: (2022)

T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis
por: Kalfaoglu, Bahire, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r95s91kfscm9t6lmmh9vduhehq