The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2

TDP-1 is the Caenorhabditis elegans ortholog of mammalian TDP-43, which is strongly implicated in the etiology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We discovered that deletion of the tdp-1 gene results in enhanced nuclear RNA interference (RNAi). As nuclear RNAi...

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Detalles Bibliográficos
Autores principales: Saldi, Tassa K., Gonzales, Patrick, Garrido-Lecca, Alfonso, Dostal, Vishantie, Roberts, Christine M., Petrucelli, Leonard, Link, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048318/
https://www.ncbi.nlm.nih.gov/pubmed/29760282
http://dx.doi.org/10.1128/MCB.00668-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048318/
https://www.ncbi.nlm.nih.gov/pubmed/29760282
http://dx.doi.org/10.1128/MCB.00668-17

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