Cargando…

The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2

TDP-1 is the Caenorhabditis elegans ortholog of mammalian TDP-43, which is strongly implicated in the etiology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We discovered that deletion of the tdp-1 gene results in enhanced nuclear RNA interference (RNAi). As nuclear RNAi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saldi, Tassa K., Gonzales, Patrick, Garrido-Lecca, Alfonso, Dostal, Vishantie, Roberts, Christine M., Petrucelli, Leonard, Link, Christopher D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048318/ https://www.ncbi.nlm.nih.gov/pubmed/29760282 http://dx.doi.org/10.1128/MCB.00668-17

Ejemplares similares

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA
por: Saldi, Tassa K, et al.
Publicado: (2014)

Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression
por: de la Cruz-Ruiz, Patricia, et al.
Publicado: (2023)

Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2
por: Garrigues, Jacob M., et al.
Publicado: (2015)

Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism
por: Meister, Peter, et al.
Publicado: (2011)

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

Neurodegeneration, Heterochromatin, and Double-Stranded RNA
por: Saldi, Tassa K, et al.
Publicado: (2019)

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
por: Dostal, Vishantie, et al.
Publicado: (2010)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies
por: Koopman, Mandy, et al.
Publicado: (2023)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
por: Latimer, Caitlin S., et al.
Publicado: (2022)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function
por: Koopman, Mandy, et al.
Publicado: (2023)

Mechanisms and models of TDP-43 proteinopathies
por: Petrucelli, Leonard
Publicado: (2012)

Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes
por: Koopman, Mandy, et al.
Publicado: (2023)

Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling
por: D’Alton, Simon, et al.
Publicado: (2014)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs different neuronally controlled behaviors and decreases fecundity
por: Koopman, Mandy, et al.
Publicado: (2023)

Orthologs of the Caenorhabditis elegans heterochronic genes have divergent functions in Caenorhabditis briggsae
por: Ivanova, Maria, et al.
Publicado: (2023)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs
por: Henricson, Anna, et al.
Publicado: (2004)

Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
por: Liang, Qifei, et al.
Publicado: (2023)

Transcriptional Repression of Hox Genes by C. elegans HP1/HPL and H1/HIS-24
por: Studencka, Maja, et al.
Publicado: (2012)

C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation
por: Josephs, Keith A., et al.
Publicado: (2019)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
por: Murakami, Aya, et al.
Publicado: (2022)

ARENA-based activity profiling of tau and TDP-43 transgenic C. elegans
por: Currey, Heather N, et al.
Publicado: (2020)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
por: Xu, Ya-Fei, et al.
Publicado: (2011)

Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans
por: Nordquist, Sarah K., et al.
Publicado: (2018)

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo
por: Kawamata, Hibiki, et al.
Publicado: (2017)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Activation of the Jasmonic Acid Pathway by Depletion of the Hydroperoxide Lyase OsHPL3 Reveals Crosstalk between the HPL and AOS Branches of the Oxylipin Pathway in Rice
por: Liu, Xiaoqiang, et al.
Publicado: (2012)

Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

An RNAi-Based Suppressor Screen Identifies Interactors of the Myt1 Ortholog of Caenorhabditis elegans
por: Allen, Anna K., et al.
Publicado: (2014)

Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity
por: Sutphin, George L., et al.
Publicado: (2017)

The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans
por: Jofré, Diego M., et al.
Publicado: (2022)

TDP-43 crosses the divide
por: Leslie, Mitch
Publicado: (2015)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Huang, Wendi, et al.
Publicado: (2020)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
por: Atkinson, Rachel, et al.
Publicado: (2021)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
por: Rengifo-Gonzalez, Juan Carlos, et al.
Publicado: (2021)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jujnnrfggub4r55bh0onm31646