Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

The formation and spreading of amyloid aggregates from the presynaptic protein α-synuclein in the brain play central roles in the pathogenesis of Parkinson’s disease. Here, we use high-resolution atomic force microscopy to investigate the early oligomerization events of α-synuclein with single monom...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruggeri, Francesco Simone, Benedetti, Fabrizio, Knowles, Tuomas P. J., Lashuel, Hilal A., Sekatskii, Sergey, Dietler, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048494/
https://www.ncbi.nlm.nih.gov/pubmed/29941606
http://dx.doi.org/10.1073/pnas.1721220115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048494/
https://www.ncbi.nlm.nih.gov/pubmed/29941606
http://dx.doi.org/10.1073/pnas.1721220115

Ejemplares similares