miR-34a directly targets tRNA(i)(Met) precursors and affects cellular proliferation, cell cycle, and apoptosis

It remains unknown whether microRNA (miRNA/miR) can target transfer RNA (tRNA) molecules. Here we provide evidence that miR-34a physically interacts with and functionally targets tRNA(i)(Met) precursors in both in vitro pulldown and Argonaute 2 (AGO2) cleavage assays. We find that miR-34a suppresses...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Li, Dongping, Kovalchuk, Igor, Apel, Ingrid J., Chinnaiyan, Arul M., Wóycicki, Rafał K., Cantor, Charles R., Kovalchuk, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048500/
https://www.ncbi.nlm.nih.gov/pubmed/29941603
http://dx.doi.org/10.1073/pnas.1703029115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048500/
https://www.ncbi.nlm.nih.gov/pubmed/29941603
http://dx.doi.org/10.1073/pnas.1703029115

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