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miR-34a directly targets tRNA(i)(Met) precursors and affects cellular proliferation, cell cycle, and apoptosis
It remains unknown whether microRNA (miRNA/miR) can target transfer RNA (tRNA) molecules. Here we provide evidence that miR-34a physically interacts with and functionally targets tRNA(i)(Met) precursors in both in vitro pulldown and Argonaute 2 (AGO2) cleavage assays. We find that miR-34a suppresses...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048500/ https://www.ncbi.nlm.nih.gov/pubmed/29941603 http://dx.doi.org/10.1073/pnas.1703029115 |