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Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during neural wiring, but the full landscape of proteomic changes remains unknown due to limitations in axon sampling and sensitivity. By combining pulsed stable isotope labeling of amino acids in cell culture with s...

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Detalles Bibliográficos
Autores principales: Cagnetta, Roberta, Frese, Christian K., Shigeoka, Toshiaki, Krijgsveld, Jeroen, Holt, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048689/
https://www.ncbi.nlm.nih.gov/pubmed/30008298
http://dx.doi.org/10.1016/j.neuron.2018.06.004