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C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

Parkinson's disease is one of the major neurodegenerative disorders affecting the ageing populations of the modern world. One of the hallmarks of this disease is the deposition of aggregates, mainly of the small pre-synaptic protein α-synuclein (AS), in the brains of patients. Several very sign...

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Detalles Bibliográficos
Autores principales:	van der Wateren, Ingrid M., Knowles, Tuomas P. J., Buell, Alexander K., Dobson, Christopher M., Galvagnion, Céline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048717/ https://www.ncbi.nlm.nih.gov/pubmed/30061982 http://dx.doi.org/10.1039/c8sc01109e

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