In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway

Clustered, regularly interspaced, short palindromic repeat (CRISPR)–CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lines has become relatively easy, editing of therapeuti...

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Detalles Bibliográficos
Autores principales: Wienert, Beeke, Shin, Jiyung, Zelin, Elena, Pestal, Kathleen, Corn, Jacob E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049001/
https://www.ncbi.nlm.nih.gov/pubmed/30011268
http://dx.doi.org/10.1371/journal.pbio.2005840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049001/
https://www.ncbi.nlm.nih.gov/pubmed/30011268
http://dx.doi.org/10.1371/journal.pbio.2005840

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