A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression

OBJECTIVE: The medicinal plants Rhodiola rosea L. (rhodiola, golden root) and Crocus sativus L. (saffron) have been shown separately to induce significant effects in depression. The objective of this study was to assess a fixed combination of rhodiola and saffron in mild–moderate depression. METHODS...

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Autores principales: Bangratz, Marie, Ait Abdellah, Samira, Berlin, Aurélie, Blondeau, Claude, Guilbot, Angèle, Dubourdeaux, Michel, Lemoine, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049049/
https://www.ncbi.nlm.nih.gov/pubmed/30034237
http://dx.doi.org/10.2147/NDT.S169575
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author Bangratz, Marie
Ait Abdellah, Samira
Berlin, Aurélie
Blondeau, Claude
Guilbot, Angèle
Dubourdeaux, Michel
Lemoine, Patrick
author_facet Bangratz, Marie
Ait Abdellah, Samira
Berlin, Aurélie
Blondeau, Claude
Guilbot, Angèle
Dubourdeaux, Michel
Lemoine, Patrick
author_sort Bangratz, Marie
collection PubMed
description OBJECTIVE: The medicinal plants Rhodiola rosea L. (rhodiola, golden root) and Crocus sativus L. (saffron) have been shown separately to induce significant effects in depression. The objective of this study was to assess a fixed combination of rhodiola and saffron in mild–moderate depression. METHODS: In this observational study conducted with general practitioners (GPs), 45 adults (aged 18–85 years) suffering from mild or moderate depression (International Statistical Classification of Diseases and Related Health Problems 10th Revision definition) and reaching a score on the Hamilton Rating Scale for Depression of 8–18 were supplemented with a combination of rhodiola and saffron extracts (one tablet, 154 mg of rhodiola and 15 mg of saffron; recommended dose two tablets per day for 6 weeks). RESULTS: After 6 weeks (D42) of supplementation, Hamilton Rating Scale for Depression scores (primary outcome) decreased significantly by 58%±28.5% (from 13.6±2.3 at D0 to 5.6±3.8 at D42, P<0.0001; n=41). Score improvement was reported in 85.4% of patients. A significant drop in both Hospital Anxiety and Depression Scale anxiety and depression scores was also observed at D42, the decrease being significant from 2 weeks of supplementation. At the end of the study, both GPs and patients deemed there was a significant improvement in depression (Clinical Global Impression – improvement and Patient Global Impression of Change). Safety was excellent, and no serious adverse effects were recorded. CONCLUSION: Results of this observational study performed in primary care suggest that the combination of rhodiola and saffron tested could be useful for the management of mild–moderate depression and improve depressive and anxiety symptoms. A double-blind placebo-controlled study is needed to confirm these results.
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spelling pubmed-60490492018-07-20 A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression Bangratz, Marie Ait Abdellah, Samira Berlin, Aurélie Blondeau, Claude Guilbot, Angèle Dubourdeaux, Michel Lemoine, Patrick Neuropsychiatr Dis Treat Original Research OBJECTIVE: The medicinal plants Rhodiola rosea L. (rhodiola, golden root) and Crocus sativus L. (saffron) have been shown separately to induce significant effects in depression. The objective of this study was to assess a fixed combination of rhodiola and saffron in mild–moderate depression. METHODS: In this observational study conducted with general practitioners (GPs), 45 adults (aged 18–85 years) suffering from mild or moderate depression (International Statistical Classification of Diseases and Related Health Problems 10th Revision definition) and reaching a score on the Hamilton Rating Scale for Depression of 8–18 were supplemented with a combination of rhodiola and saffron extracts (one tablet, 154 mg of rhodiola and 15 mg of saffron; recommended dose two tablets per day for 6 weeks). RESULTS: After 6 weeks (D42) of supplementation, Hamilton Rating Scale for Depression scores (primary outcome) decreased significantly by 58%±28.5% (from 13.6±2.3 at D0 to 5.6±3.8 at D42, P<0.0001; n=41). Score improvement was reported in 85.4% of patients. A significant drop in both Hospital Anxiety and Depression Scale anxiety and depression scores was also observed at D42, the decrease being significant from 2 weeks of supplementation. At the end of the study, both GPs and patients deemed there was a significant improvement in depression (Clinical Global Impression – improvement and Patient Global Impression of Change). Safety was excellent, and no serious adverse effects were recorded. CONCLUSION: Results of this observational study performed in primary care suggest that the combination of rhodiola and saffron tested could be useful for the management of mild–moderate depression and improve depressive and anxiety symptoms. A double-blind placebo-controlled study is needed to confirm these results. Dove Medical Press 2018-07-13 /pmc/articles/PMC6049049/ /pubmed/30034237 http://dx.doi.org/10.2147/NDT.S169575 Text en © 2018 Bangratz et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Bangratz, Marie
Ait Abdellah, Samira
Berlin, Aurélie
Blondeau, Claude
Guilbot, Angèle
Dubourdeaux, Michel
Lemoine, Patrick
A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
title A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
title_full A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
title_fullStr A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
title_full_unstemmed A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
title_short A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
title_sort preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049049/
https://www.ncbi.nlm.nih.gov/pubmed/30034237
http://dx.doi.org/10.2147/NDT.S169575
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