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tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are abundant small RNAs reported to be associated with Argonaute proteins, yet their function is unclear. We show that endogenous 18 nucleotide tRFs derived from the 3′ ends of tRNAs (tRF-3) post-transcriptionally repress g...

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Detalles Bibliográficos
Autores principales: Kuscu, Canan, Kumar, Pankaj, Kiran, Manjari, Su, Zhangli, Malik, Asrar, Dutta, Anindya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049499/
https://www.ncbi.nlm.nih.gov/pubmed/29844106
http://dx.doi.org/10.1261/rna.066126.118