Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

The recent identification of compounds that interact with the spliceosome (sudemycins, spliceostatin A, and meayamycin) indicates that these molecules modulate aberrant splicing via SF3B1 inhibition. Through whole transcriptome sequencing, we have demonstrated that treatment of Rh18 cells with sudem...

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Detalles Bibliográficos
Autores principales: Wu, Gang, Fan, Liying, Edmonson, Michael N., Shaw, Timothy, Boggs, Kristy, Easton, John, Rusch, Michael C., Webb, Thomas R., Zhang, Jinghui, Potter, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049506/
https://www.ncbi.nlm.nih.gov/pubmed/29844105
http://dx.doi.org/10.1261/rna.065383.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049506/
https://www.ncbi.nlm.nih.gov/pubmed/29844105
http://dx.doi.org/10.1261/rna.065383.117

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