Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor

Angiogenin (ANG) is a secretory ribonuclease that promotes the proliferation of endothelial cells, leading to angiogenesis. This function relies on its ribonucleolytic activity, which is low for simple RNA substrates. Upon entry into the cytosol, ANG is sequestered by the ribonuclease inhibitor prot...

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Detalles Bibliográficos
Autores principales: Thomas, Sydney P., Hoang, Trish T., Ressler, Valerie T., Raines, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049508/
https://www.ncbi.nlm.nih.gov/pubmed/29748193
http://dx.doi.org/10.1261/rna.065516.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049508/
https://www.ncbi.nlm.nih.gov/pubmed/29748193
http://dx.doi.org/10.1261/rna.065516.117

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