A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is currently available for ADPKD. Here we identify the Hippo signaling effector YAP and its transcriptional target, c-Myc, as promot...

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Detalles Bibliográficos
Autores principales: Cai, Jing, Song, Xuewen, Wang, Wei, Watnick, Terry, Pei, York, Qian, Feng, Pan, Duojia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049514/
https://www.ncbi.nlm.nih.gov/pubmed/29891559
http://dx.doi.org/10.1101/gad.315127.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049514/
https://www.ncbi.nlm.nih.gov/pubmed/29891559
http://dx.doi.org/10.1101/gad.315127.118

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