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Polycystic kidney disease: a Hippo connection

Mutations in PKD1 and PKD2 are the leading cause of autosomal dominant polycystic kidney disease (ADPKD). In this issue of Genes & Development, a report by Cai and colleagues (pp. 781–793) reveals new insight into the molecular basis by which PKD1 deficiency leads to cystic kidney pathogenesis....

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Detalles Bibliográficos
Autores principales: Ma, Shenghong, Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049516/
https://www.ncbi.nlm.nih.gov/pubmed/29921661
http://dx.doi.org/10.1101/gad.316570.118
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author Ma, Shenghong
Guan, Kun-Liang
author_facet Ma, Shenghong
Guan, Kun-Liang
author_sort Ma, Shenghong
collection PubMed
description Mutations in PKD1 and PKD2 are the leading cause of autosomal dominant polycystic kidney disease (ADPKD). In this issue of Genes & Development, a report by Cai and colleagues (pp. 781–793) reveals new insight into the molecular basis by which PKD1 deficiency leads to cystic kidney pathogenesis. By using extensive mouse genetic analyses coupled with in vitro cystic assays, the investigators delineate a RhoA–YAP–c-Myc signaling axis as a key downstream from PKD1 deficiency in ADPKD pathogenesis. Their findings provide evidence that the Hippo pathway could be a potential target for treating ADPKD.
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spelling pubmed-60495162018-12-01 Polycystic kidney disease: a Hippo connection Ma, Shenghong Guan, Kun-Liang Genes Dev Outlook Mutations in PKD1 and PKD2 are the leading cause of autosomal dominant polycystic kidney disease (ADPKD). In this issue of Genes & Development, a report by Cai and colleagues (pp. 781–793) reveals new insight into the molecular basis by which PKD1 deficiency leads to cystic kidney pathogenesis. By using extensive mouse genetic analyses coupled with in vitro cystic assays, the investigators delineate a RhoA–YAP–c-Myc signaling axis as a key downstream from PKD1 deficiency in ADPKD pathogenesis. Their findings provide evidence that the Hippo pathway could be a potential target for treating ADPKD. Cold Spring Harbor Laboratory Press 2018-06-01 /pmc/articles/PMC6049516/ /pubmed/29921661 http://dx.doi.org/10.1101/gad.316570.118 Text en © 2018 Ma and Guan; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Ma, Shenghong
Guan, Kun-Liang
Polycystic kidney disease: a Hippo connection
title Polycystic kidney disease: a Hippo connection
title_full Polycystic kidney disease: a Hippo connection
title_fullStr Polycystic kidney disease: a Hippo connection
title_full_unstemmed Polycystic kidney disease: a Hippo connection
title_short Polycystic kidney disease: a Hippo connection
title_sort polycystic kidney disease: a hippo connection
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049516/
https://www.ncbi.nlm.nih.gov/pubmed/29921661
http://dx.doi.org/10.1101/gad.316570.118
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