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Polycystic kidney disease: a Hippo connection
Mutations in PKD1 and PKD2 are the leading cause of autosomal dominant polycystic kidney disease (ADPKD). In this issue of Genes & Development, a report by Cai and colleagues (pp. 781–793) reveals new insight into the molecular basis by which PKD1 deficiency leads to cystic kidney pathogenesis....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049516/ https://www.ncbi.nlm.nih.gov/pubmed/29921661 http://dx.doi.org/10.1101/gad.316570.118 |
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author | Ma, Shenghong Guan, Kun-Liang |
author_facet | Ma, Shenghong Guan, Kun-Liang |
author_sort | Ma, Shenghong |
collection | PubMed |
description | Mutations in PKD1 and PKD2 are the leading cause of autosomal dominant polycystic kidney disease (ADPKD). In this issue of Genes & Development, a report by Cai and colleagues (pp. 781–793) reveals new insight into the molecular basis by which PKD1 deficiency leads to cystic kidney pathogenesis. By using extensive mouse genetic analyses coupled with in vitro cystic assays, the investigators delineate a RhoA–YAP–c-Myc signaling axis as a key downstream from PKD1 deficiency in ADPKD pathogenesis. Their findings provide evidence that the Hippo pathway could be a potential target for treating ADPKD. |
format | Online Article Text |
id | pubmed-6049516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60495162018-12-01 Polycystic kidney disease: a Hippo connection Ma, Shenghong Guan, Kun-Liang Genes Dev Outlook Mutations in PKD1 and PKD2 are the leading cause of autosomal dominant polycystic kidney disease (ADPKD). In this issue of Genes & Development, a report by Cai and colleagues (pp. 781–793) reveals new insight into the molecular basis by which PKD1 deficiency leads to cystic kidney pathogenesis. By using extensive mouse genetic analyses coupled with in vitro cystic assays, the investigators delineate a RhoA–YAP–c-Myc signaling axis as a key downstream from PKD1 deficiency in ADPKD pathogenesis. Their findings provide evidence that the Hippo pathway could be a potential target for treating ADPKD. Cold Spring Harbor Laboratory Press 2018-06-01 /pmc/articles/PMC6049516/ /pubmed/29921661 http://dx.doi.org/10.1101/gad.316570.118 Text en © 2018 Ma and Guan; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Outlook Ma, Shenghong Guan, Kun-Liang Polycystic kidney disease: a Hippo connection |
title | Polycystic kidney disease: a Hippo connection |
title_full | Polycystic kidney disease: a Hippo connection |
title_fullStr | Polycystic kidney disease: a Hippo connection |
title_full_unstemmed | Polycystic kidney disease: a Hippo connection |
title_short | Polycystic kidney disease: a Hippo connection |
title_sort | polycystic kidney disease: a hippo connection |
topic | Outlook |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049516/ https://www.ncbi.nlm.nih.gov/pubmed/29921661 http://dx.doi.org/10.1101/gad.316570.118 |
work_keys_str_mv | AT mashenghong polycystickidneydiseaseahippoconnection AT guankunliang polycystickidneydiseaseahippoconnection |