Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

Abnormalities in nucleic acid processing are associated with the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin 3 (MATR3), a poorly understood DNA- and RNA-binding protein, cause familial ALS/FTD, and MATR3 pathology is a feature of sporadic...

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Detalles Bibliográficos
Autores principales: Malik, Ahmed M, Miguez, Roberto A, Li, Xingli, Ho, Ye-Shih, Feldman, Eva L, Barmada, Sami J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050042/
https://www.ncbi.nlm.nih.gov/pubmed/30015619
http://dx.doi.org/10.7554/eLife.35977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050042/
https://www.ncbi.nlm.nih.gov/pubmed/30015619
http://dx.doi.org/10.7554/eLife.35977

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