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Isolated domains of recombinant human apo-metallothionein 1A are folded at neutral pH: a denaturant and heat-induced unfolding study using ESI-MS

Metallothioneins (MTs) are characterized by their high metal loading capacity, small molecular weight, and abundant cysteine residues. It has long been thought that metal-free, or apo-MT peptides were unstructured and only adopted as a distinct conformation upon forming the metal clusters, described...

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Detalles Bibliográficos
Autores principales: Irvine, Gordon W., Korkola, Natalie, Stillman, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050192/
https://www.ncbi.nlm.nih.gov/pubmed/29858425
http://dx.doi.org/10.1042/BSR20180592