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Peptide Sequence Influence on the Conformational Dynamics and DNA binding of the Intrinsically Disordered AT-Hook 3 Peptide

The intrinsically disordered ATHP3 was studied at native conditions and in complex with DNA using single amino acid substitutions and high-resolution ion mobility spectrometry coupled to mass spectrometry (trapped IMS-MS). Results showed that ATHP3 can exist in multiple conformations at native condi...

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Detalles Bibliográficos
Autores principales: Garabedian, Alyssa, Bolufer, Alexander, Leng, Fenfei, Fernandez-Lima, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050235/
https://www.ncbi.nlm.nih.gov/pubmed/30018295
http://dx.doi.org/10.1038/s41598-018-28956-z