Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides

Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we...

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Detalles Bibliográficos
Autores principales: Saravanan, Rathi, Holdbrook, Daniel A, Petrlova, Jitka, Singh, Shalini, Berglund, Nils A, Choong, Yeu Khai, Kjellström, Sven, Bond, Peter J, Malmsten, Martin, Schmidtchen, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050251/
https://www.ncbi.nlm.nih.gov/pubmed/30018388
http://dx.doi.org/10.1038/s41467-018-05242-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050251/
https://www.ncbi.nlm.nih.gov/pubmed/30018388
http://dx.doi.org/10.1038/s41467-018-05242-0

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