Buparlisib is a brain penetrable pan-PI3K inhibitor

Characterization of the genomic landscapes of intracranial tumours has revealed a clear role for the PI3K-AKT-mTOR pathway in tumorigenesis and tumour maintenance of these malignancies, making phosphatidylinositol 3-kinase (PI3K) inhibition a promising therapeutic strategy for these tumours. Buparli...

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Detalles Bibliográficos
Autores principales: de Gooijer, Mark C., Zhang, Ping, Buil, Levi C. M., Çitirikkaya, Ceren H., Thota, Nishita, Beijnen, Jos H., van Tellingen, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050274/
https://www.ncbi.nlm.nih.gov/pubmed/30018387
http://dx.doi.org/10.1038/s41598-018-29062-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050274/
https://www.ncbi.nlm.nih.gov/pubmed/30018387
http://dx.doi.org/10.1038/s41598-018-29062-w

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