A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis

Cyclopropanation of unactivated olefinic bonds via addition of a reactive one-carbon species is well developed in synthetic chemistry, whereas natural cyclopropane biosynthesis employing this strategy is very limited. Here, we identify a two-component cyclopropanase system, composed of a HemN-like r...

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Detalles Bibliográficos
Autores principales: Jin, Wen-Bing, Wu, Sheng, Jian, Xiao-Hong, Yuan, Hua, Tang, Gong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050322/
https://www.ncbi.nlm.nih.gov/pubmed/30018376
http://dx.doi.org/10.1038/s41467-018-05217-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050322/
https://www.ncbi.nlm.nih.gov/pubmed/30018376
http://dx.doi.org/10.1038/s41467-018-05217-1

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