The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model

Genome reassortment in Lassa virus (LASV) has been reported in nature, but phenotypic consequences of this phenomenon are not well described. Here we characterize, both in vitro and in vivo, reassortment between 2 LASV strains: the prototypic 1976 Josiah strain and a more recently isolated 2015 Libe...

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Detalles Bibliográficos
Autores principales: Welch, Stephen R., Scholte, Florine E. M., Albariño, César G., Kainulainen, Markus H., Coleman-McCray, JoAnn D., Guerrero, Lisa Wiggleton, Chakrabarti, Ayan K., Klena, John D., Nichol, Stuart T., Spengler, Jessica R., Spiropoulou, Christina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050391/
https://www.ncbi.nlm.nih.gov/pubmed/30050872
http://dx.doi.org/10.3389/fcimb.2018.00240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050391/
https://www.ncbi.nlm.nih.gov/pubmed/30050872
http://dx.doi.org/10.3389/fcimb.2018.00240

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