LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation, increases its kinase activity. LRRK2 regulates mitochondria morphology and autophagy...

Descripción completa

Detalles Bibliográficos
Autores principales: Ho, Dong Hwan, Je, A Reum, Lee, Haejin, Son, Ilhong, Kweon, Hee-Seok, Kim, Hyung-Gun, Seol, Wongi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050415/
https://www.ncbi.nlm.nih.gov/pubmed/30022868
http://dx.doi.org/10.5607/en.2018.27.3.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050415/
https://www.ncbi.nlm.nih.gov/pubmed/30022868
http://dx.doi.org/10.5607/en.2018.27.3.171

Ejemplares similares