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Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load
The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigation in correlation studies with postmortem meas...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050460/ https://www.ncbi.nlm.nih.gov/pubmed/30023168 http://dx.doi.org/10.1016/j.nicl.2018.04.007 |
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author | Minhas, Davneet S. Price, Julie C. Laymon, Charles M. Becker, Carl R. Klunk, William E. Tudorascu, Dana L. Abrahamson, Eric E. Hamilton, Ronald L. Kofler, Julia K. Mathis, Chester A. Lopez, Oscar L. Ikonomovic, Milos D. |
author_facet | Minhas, Davneet S. Price, Julie C. Laymon, Charles M. Becker, Carl R. Klunk, William E. Tudorascu, Dana L. Abrahamson, Eric E. Hamilton, Ronald L. Kofler, Julia K. Mathis, Chester A. Lopez, Oscar L. Ikonomovic, Milos D. |
author_sort | Minhas, Davneet S. |
collection | PubMed |
description | The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigation in correlation studies with postmortem measures of Aβ pathology. One potential confound in PET-to-postmortem correlation studies is the limited spatial resolution of PET and resulting partial volume effects (PVEs). In this work, we evaluated the impact of three partial volume correction (PVC) techniques – the Meltzer, the modified Müller-Gärtner, and the Region-Based Voxel-Wise – on correlations between region-matched in vivo [C-11]PiB standardized uptake value ratios (SUVRs) and postmortem measures of Aβ pathology in a unique cohort of nine subjects. Postmortem Aβ pathology was assessed histologically as percent area coverage of 6-CN-PiB positive and Aβ immunoreactive (4G8 antibody) deposits. The application of all three PVC techniques resulted in minimally reduced PET-to-postmortem correlations relative to no PVC. However, correlations to both 6-CN-PiB and 4G8 percent area across all PVC techniques and no PVC were statistically significant at p < 0.01, suggesting that PVC is of minimal importance in understanding the relationship between Aβ PET and neuropathologically assessed Aβ. Thus, the utility of PVC in Aβ PET imaging should continue to be examined on an application-specific basis. |
format | Online Article Text |
id | pubmed-6050460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60504602018-07-18 Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load Minhas, Davneet S. Price, Julie C. Laymon, Charles M. Becker, Carl R. Klunk, William E. Tudorascu, Dana L. Abrahamson, Eric E. Hamilton, Ronald L. Kofler, Julia K. Mathis, Chester A. Lopez, Oscar L. Ikonomovic, Milos D. Neuroimage Clin Regular Article The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigation in correlation studies with postmortem measures of Aβ pathology. One potential confound in PET-to-postmortem correlation studies is the limited spatial resolution of PET and resulting partial volume effects (PVEs). In this work, we evaluated the impact of three partial volume correction (PVC) techniques – the Meltzer, the modified Müller-Gärtner, and the Region-Based Voxel-Wise – on correlations between region-matched in vivo [C-11]PiB standardized uptake value ratios (SUVRs) and postmortem measures of Aβ pathology in a unique cohort of nine subjects. Postmortem Aβ pathology was assessed histologically as percent area coverage of 6-CN-PiB positive and Aβ immunoreactive (4G8 antibody) deposits. The application of all three PVC techniques resulted in minimally reduced PET-to-postmortem correlations relative to no PVC. However, correlations to both 6-CN-PiB and 4G8 percent area across all PVC techniques and no PVC were statistically significant at p < 0.01, suggesting that PVC is of minimal importance in understanding the relationship between Aβ PET and neuropathologically assessed Aβ. Thus, the utility of PVC in Aβ PET imaging should continue to be examined on an application-specific basis. Elsevier 2018-04-04 /pmc/articles/PMC6050460/ /pubmed/30023168 http://dx.doi.org/10.1016/j.nicl.2018.04.007 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Minhas, Davneet S. Price, Julie C. Laymon, Charles M. Becker, Carl R. Klunk, William E. Tudorascu, Dana L. Abrahamson, Eric E. Hamilton, Ronald L. Kofler, Julia K. Mathis, Chester A. Lopez, Oscar L. Ikonomovic, Milos D. Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load |
title | Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load |
title_full | Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load |
title_fullStr | Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load |
title_full_unstemmed | Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load |
title_short | Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load |
title_sort | impact of partial volume correction on the regional correspondence between in vivo [c-11]pib pet and postmortem measures of aβ load |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050460/ https://www.ncbi.nlm.nih.gov/pubmed/30023168 http://dx.doi.org/10.1016/j.nicl.2018.04.007 |
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