Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor

Characterizing the mode of action of non-covalent inhibitors in multisubunit enzymes often presents a great challenge. Most of the conventionally used methods are based on ensemble measurements of protein–ligand binding in bulk solution. They often fail to accurately describe multiple binding proces...

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Detalles Bibliográficos
Autores principales: Root, Katharina, Barylyuk, Konstantin, Schwab, Anatol, Thelemann, Jonas, Illarionov, Boris, Geist, Julie G., Gräwert, Tobias, Bacher, Adelbert, Fischer, Markus, Diederich, François, Zenobi, Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050538/
https://www.ncbi.nlm.nih.gov/pubmed/30079212
http://dx.doi.org/10.1039/c8sc00814k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050538/
https://www.ncbi.nlm.nih.gov/pubmed/30079212
http://dx.doi.org/10.1039/c8sc00814k

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